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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM362665
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent  US10227359 Publication Date 3/12/2019 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM362665
Synonyms:
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}-N- methylcyclobutanecarboxamide | US10227359, Example 20 | US9834565, Example 20
Type:
Small organic molecule
Emp. Form.:
C30H34N6O3
Mol. Mass.:
526.6294
SMILES:
CN(C1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccn4)n1c23)C(=O)C1CCC1 |(-1.28,6.6,;-2.05,5.27,;-1.28,3.94,;-2.05,2.6,;-1.28,1.27,;.26,1.27,;1.03,2.6,;.26,3.94,;1.03,-.07,;2.57,-.07,;3.13,-1.5,;4.47,-2.27,;4.47,-3.81,;3.13,-4.58,;3.13,-6.12,;1.89,-7.02,;.42,-6.55,;2.36,-8.49,;3.9,-8.49,;4.38,-7.02,;5.84,-6.55,;1.8,-3.81,;.47,-4.58,;-.87,-3.81,;-.87,-2.27,;-2.2,-1.5,;-3.53,-2.27,;-4.87,-1.5,;-4.87,.04,;-3.53,.81,;-2.2,.04,;.47,-1.5,;1.8,-2.27,;-3.59,5.27,;-4.36,3.94,;-4.36,6.6,;-5.84,7,;-5.45,8.49,;-3.96,8.09,)|
Structure:
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