Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM369459
Substrate
n/a
Meas. Tech.
S-Adenosylhomocysteine Hydrolase (SAHase) Inhibition
IC50
27.0±n/a nM
Citation
 Schneller, SW; Liu, C; Chen, Q; Ye, W Enantiomers of the 1′,6′-isomer of neplanocin A US Patent  US10227373 Publication Date 3/12/2019 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | S-Adenosylhomocysteine Hydrolase | SAHase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58521.01
Organism:
Oryctolagus cuniculus (Rabbit)
Description:
n/a
Residue:
536
Sequence:
MKGTIMARCPLGKPSRRSIDSTGQNSESGAGIEVHSGHAPVRGPRPCRLSLSGTHEYAKRGRYLKAPAPRADSCPAPPAQCLISALGLIPFSPVCITACSNAARMSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMANGVLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWTHPDKYAVGVHFLPKKLDEAVAEAHLSKLNVKLTKLTEKQAQYLGMSRDGPFKPDHYRY
  
Inhibitor
Name:
BDBM369459
Synonyms:
US10227373, Compound L-Isoneplanocin
Type:
Small organic molecule
Emp. Form.:
C11H13N5O3
Mol. Mass.:
263.2526
SMILES:
Nc1ncnc2n(cnc12)C1=C[C@@H](CO)[C@@H](O)[C@H]1O |r,t:12|
Structure:
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