Reaction Details Report a problem with these data
Target
Orotidine-5'-phosphate decarboxylase
Ligand
BDBM21338
Substrate
BDBM21336
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
310.15±n/a K
Ki
2100±n/a nM
Citation
 Bello, AM; Poduch, E; Liu, Y; Wei, L; Crandall, I; Wang, X; Dyanand, C; Kain, KC; Pai, EF; Kotra, LP Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase. J Med Chem 51:439-48 (2008) [PubMed]  Article 
Target
Name:
Orotidine-5'-phosphate decarboxylase
Synonyms:
ODCase | Orotidine 5-Phosphate Decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase)
Type:
Enzyme
Mol. Mass.:
37826.43
Organism:
Plasmodium falciparum (malaria parasite P. falciparum)
Description:
n/a
Residue:
323
Sequence:
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKEKYINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALTFKMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNPYPQKAAQMYYDQINAILKQNMES
  
Inhibitor
Name:
BDBM21338
Synonyms:
6-Amino-uridine 5-O-Monophosphate | C6-Uridine Derivative, 15 | JMC521648 Compound 37 | {[(2R,3S,4R,5R)-5-(6-amino-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C9H14N3O9P
Mol. Mass.:
339.1959
SMILES:
Nc1cc(=O)[nH]c(=O)n1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21336
Synonyms:
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | OMP | orotidine 5-monophosphate | orotidylic acid
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H13N2O11P
Mol. Mass.:
368.1908
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(cc(=O)[nH]c1=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: