Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM254008
Substrate
n/a
Meas. Tech.
MDM2-p53 TR-FRET Binding Assa
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
3.60±n/a nM
Comments
extracted
Citation
 Chen, YDing, QSun, Y Spiropyrrolidines as MDM2 inhibitors US Patent  US9701685 Publication Date 7/11/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM254008
Synonyms:
US9701685, 10 | US9701685, 65 | racemic 4-[[(2''R,3R,3''S,5''S)-6-chloro-3''-(3-chloro-2-fluoro-phenyl)-2-oxo-5''-[(2S)-3,3,3-trifluoro-2-methyl-propyl]spiro[indoline-3,4''-pyrrolidine]-2''-carbonyl]amino]-3-methoxy-benzoic acid
Type:
Small organic molecule
Emp. Form.:
C30H25Cl2F4N3O5
Mol. Mass.:
654.436
SMILES:
COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](C[C@H](C)C(F)(F)F)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: