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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM254021
Substrate
n/a
Meas. Tech.
MDM2-p53 TR-FRET Binding Assa
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
7.20±n/a nM
Comments
extracted
Citation
 Chen, Y; Ding, Q; Sun, Y Spiropyrrolidines as MDM2 inhibitors US Patent  US9701685 Publication Date 7/11/2017 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM254021
Synonyms:
US9701685, 73 | racemic 4-{[6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(1-fluoromethyl-cyclopropylmethyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]e-5'-carbonyl]-amino}-3-methoxy-benzoic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C32H29Cl2F2N3O5
Mol. Mass.:
644.493
SMILES:
COC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC3(CF)CC3)C3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)c(OC)c1 |r|
Structure:
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