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TargetApoptosis regulator Bcl-2
LigandBDBM21436
Substrate/CompetitorFluorescein-labeled BAX peptide
Meas. Tech.Fluorescence Polarization Assay and FL5.12 Cellular Assay
Ki<1±n/a nM
EC50 130±n/a nM
Citation Bruncko, MOost, TKBelli, BADing, HJoseph, MKKunzer, AMartineau, DMcClellan, WJMitten, MNg, SCNimmer, PMOltersdorf, TPark, CMPetros, AMShoemaker, ARSong, XWang, XWendt, MDZhang, HFesik, SWRosenberg, SHElmore, SW Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem50:641-62 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM21436
NameBDBM21436
Synonyms:N-Benylpiperazine derivative, 23d | N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-(4-{[2-(methylsulfanyl)phenyl]methyl}piperazin-1-yl)benzamide
TypeSmall organic molecule
Emp. Form.C37H44N6O5S3
Mol. Mass.748.977
SMILESCSc1ccccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)[N+]([O-])=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Fluorescein-labeled BAX peptide
Name:Fluorescein-labeled BAX peptide
Synonyms:n/a
Type:fluorescein-labeled probe
Mol. Mass.:2800.15
Organism:n/a
Description:n/a
Residue:25
Sequence:
FITC-QDASTKKLSECLKRIGDELDS