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TargetApoptosis regulator Bcl-2
LigandBDBM21444
Substrate/CompetitorFluorescein-labeled BAX peptide
Meas. Tech.Fluorescence Polarization Assay and FL5.12 Cellular Assay
Ki<1±n/a nM
EC50 25±n/a nM
Citation Bruncko, MOost, TKBelli, BADing, HJoseph, MKKunzer, AMartineau, DMcClellan, WJMitten, MNg, SCNimmer, PMOltersdorf, TPark, CMPetros, AMShoemaker, ARSong, XWang, XWendt, MDZhang, HFesik, SWRosenberg, SHElmore, SW Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem50:641-62 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM21444
NameBDBM21444
Synonyms:N-Benylpiperazine derivative, 23m | N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-(4-{[2-(4-methoxyphenyl)phenyl]methyl}piperazin-1-yl)benzamide
TypeSmall organic molecule
Emp. Form.C43H48N6O6S2
Mol. Mass.809.008
SMILESCOc1ccc(cc1)-c1ccccc1CN1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN(C)C)CSc2ccccc2)c(c1)[N+]([O-])=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
Fluorescein-labeled BAX peptide
Name:Fluorescein-labeled BAX peptide
Synonyms:n/a
Type:fluorescein-labeled probe
Mol. Mass.:2800.15
Organism:n/a
Description:n/a
Residue:25
Sequence:
FITC-QDASTKKLSECLKRIGDELDS