Reaction Details Report a problem with these data
Target
Carboxypeptidase A1
Ligand
BDBM21471
Substrate
BDBM21477
Meas. Tech.
Enzyme Inhibition Assay
Ki
0.3±n/a nM
Citation
 Mores, A; Matziari, M; Beau, F; Cuniasse, P; Yiotakis, A; Dive, V Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. J Med Chem 51:2216-2226 (2008) [PubMed]  Article 
Target
Name:
Carboxypeptidase A1
Synonyms:
CBPA1_BOVIN | CPA | CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor
Type:
Enzyme
Mol. Mass.:
47073.90
Organism:
Bos taurus (bovine)
Description:
From Sigma-Aldrich Co.
Residue:
419
Sequence:
MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPGSPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTRSVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFKAFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQASGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
  
Inhibitor
Name:
BDBM21471
Synonyms:
2-benzyl-3-{[1-(2-acetamido-4-methylpentanamido)-2-phenylethyl](hydroxy)phosphoryl}propanoic acid | Phosphinic Peptide Inhibitor, 35
Type:
Small organic molecule
Emp. Form.:
C26H35N2O6P
Mol. Mass.:
502.5397
SMILES:
CC(C)CC(NC(C)=O)C(=O)NC(Cc1ccccc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Structure:
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Substrate
Name:
BDBM21477
Synonyms:
(2S)-2-[(2S)-2-[(2E)-3-(furan-2-yl)prop-2-enamido]-3-phenylpropanamido]-3-phenylpropanoic acid | FAPP | Furyl-acryloyl-phe-phe | Furylacryloyl-Phe-Phe | N- (3- [2-furyl] acryloyl)-phe-phe
Type:
n/a
Emp. Form.:
C25H24N2O5
Mol. Mass.:
432.4685
SMILES:
OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccco1
Structure:
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