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TargetCarboxypeptidase A1
LigandBDBM21473
Substrate/CompetitorBDBM21477
Meas. Tech.Enzyme Inhibition Assay
Ki 35±n/a nM
Citation Mores, AMatziari, MBeau, FCuniasse, PYiotakis, ADive, V Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. J Med Chem51:2216-2226 (2008) [PubMed]  Article
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Carboxypeptidase A1
Name:Carboxypeptidase A1
Synonyms:CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor
Type:Enzyme
Mol. Mass.:47073.90
Organism:Bos taurus (bovine)
Description:From Sigma-Aldrich Co.
Residue:419
Sequence:
MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPG
SPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYA
TYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHS
REWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTR
SVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFK
AFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQA
SGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
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BDBM21473
NameBDBM21473
Synonyms:3-{[1-(2-acetamido-4-methylpentanoyl)pyrrolidin-2-yl](hydroxy)phosphoryl}-2-[(3-phenyl-1,2-oxazol-5-yl)methyl]propanoic acid | Phosphinic Peptide Inhibitor, 40 FII | The second fraction of the HPLC chromatogram.
TypeSmall organic molecule
Emp. Form.C25H34N3O7P
Mol. Mass.519.5271
SMILESCC(C)CC(NC(C)=O)C(=O)N1CCC=C1P(O)(O)CC(Cc1cc(no1)-c1ccccc1)C(O)=O |c:14|
Structure
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BDBM21477
NameBDBM21477
Synonyms:(2S)-2-[(2S)-2-[(2E)-3-(furan-2-yl)prop-2-enamido]-3-phenylpropanamido]-3-phenylpropanoic acid | FAPP | Furyl-acryloyl-phe-phe | Furylacryloyl-Phe-Phe | N- (3- [2-furyl] acryloyl)-phe-phe
Typen/a
Emp. Form.C25H24N2O5
Mol. Mass.432.4685
SMILESOC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccco1
Structure
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