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Target
Carboxypeptidase A1
Ligand
BDBM21488
Substrate
BDBM21477
Meas. Tech.
CPA Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
>10000±n/a nM
Citation
 Dales, NA; Gould, AE; Brown, JA; Calderwood, EF; Guan, B; Minor, CA; Gavin, JM; Hales, P; Kaushik, VK; Stewart, M; Tummino, PJ; Vickers, CS; Ocain, TD; Patane, MA Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc 124:11852-3 (2002) [PubMed]  Article 
Target
Name:
Carboxypeptidase A1
Synonyms:
CBPA1_BOVIN | CPA | CPA1 | Carboxypeptidase A | Carboxypeptidase A (CPA) | Carboxypeptidase A1 precursor
Type:
Enzyme
Mol. Mass.:
47073.90
Organism:
Bos taurus (bovine)
Description:
From Sigma-Aldrich Co.
Residue:
419
Sequence:
MQGLLILSVLLGAALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPGSPIDVRVPFPSLQAVKVFLEAHGIRYRIMIEDVQSLLDEEQEQMFASQSRARSTNTFNYATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQATGVWFAKKFTEDYGQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQNRLWRKTRSVTSSSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVEVKSIVDFVKDHGNFKAFLSIHSYSQLLLYPYGYTTQSIPDKTELNQVAKSAVEALKSLYGTSYKYGSIITTIYQASGGSIDWSYNQGIKYSFTFELRDTGRYGFLLPASQIIPTAQETWLGVLTIMEHTLNNLY
  
Inhibitor
Name:
BDBM21488
Synonyms:
(2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dimethylphenyl)methyl]-1H-imidazol-5-yl}ethyl]amino}-4-methylpentanoic acid | Amino dicarboxylate analogue, 15
Type:
Small organic molecule
Emp. Form.:
C21H29N3O4
Mol. Mass.:
387.4727
SMILES:
CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(C)cc(C)c1)C(O)=O)C(O)=O |r|
Structure:
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Substrate
Name:
BDBM21477
Synonyms:
(2S)-2-[(2S)-2-[(2E)-3-(furan-2-yl)prop-2-enamido]-3-phenylpropanamido]-3-phenylpropanoic acid | FAPP | Furyl-acryloyl-phe-phe | Furylacryloyl-Phe-Phe | N- (3- [2-furyl] acryloyl)-phe-phe
Type:
n/a
Emp. Form.:
C25H24N2O5
Mol. Mass.:
432.4685
SMILES:
OC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccco1
Structure:
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