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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM21613
Substrate
BDBM21614
Meas. Tech.
In Vitro GST Activity Assay
pH
7.2±n/a
Temperature
295.15±n/a K
IC50
11600±n/a nM
Citation
 Hohwy, M; Spadola, L; Lundquist, B; Hawtin, P; Dahmén, J; Groth-Clausen, I; Nilsson, E; Persdotter, S; von Wachenfeldt, K; Folmer, RH; Edman, K Novel prostaglandin d synthase inhibitors generated by fragment-based drug design. J Med Chem 51:2178-86 (2008) [PubMed]  Article 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
GSTS | Glutathione-dependent PGD synthetase | Glutathione-requiring prostaglandin D synthase | H-PGDS | HPGDS | HPGDS_HUMAN | Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Hematopoietic prostaglandin D synthase (HPGDS) | PGDS | PTGDS2 | Prostaglandin D | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Homo sapiens (Human)
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM21613
Synonyms:
2-[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid | N-(3 ,4 -dimethoxycinnamoyl)anthranilic acid | Rizaben | Tranilast
Type:
Small organic molecule
Emp. Form.:
C18H17NO5
Mol. Mass.:
327.3313
SMILES:
COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21614
Synonyms:
3-(chloromethyl)-2,5,6-trimethyl-1H,7H-[1,2]diazolo[1,2-a]pyrazole-1,7-dione | Chlorobimane | MCB | MonoChloroBimane
Type:
chromogenic probe
Emp. Form.:
C10H11ClN2O2
Mol. Mass.:
226.66
SMILES:
Cc1c(C)c(=O)n2n1c(CCl)c(C)c2=O
Structure:
Search PDB for entries with ligand similarity: