Reaction Details Report a problem with these data
Target
Bile acid receptor
Ligand
BDBM370072
Substrate
n/a
Meas. Tech.
FXR Agonist Assay
EC50
<200±n/a nM
Citation
 Pratt, BA; Mohan, R Fused bicyclic compounds for the treatment of disease US Patent  US10233187 Publication Date 3/19/2019 
Target
Name:
Bile acid receptor
Synonyms:
BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor
Type:
Nuclear Receptor
Mol. Mass.:
55916.24
Organism:
Homo sapiens (Human)
Description:
Q96RI1
Residue:
486
Sequence:
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
  
Inhibitor
Name:
BDBM370072
Synonyms:
US10233187, Example 10
Type:
Small organic molecule
Emp. Form.:
C22H23F2N3O4
Mol. Mass.:
431.4325
SMILES:
CC(C)OC(=O)C1=CN(CC(C)(C)c2c(n[nH]c12)C(C)=O)C(=O)c1ccc(F)c(F)c1 |t:6|
Structure:
Search PDB for entries with ligand similarity: