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Target
Proto-oncogene tyrosine-protein kinase receptor Ret
Ligand
BDBM370407
Substrate
n/a
Meas. Tech.
Measurement of RET Inhibitory Activity
IC50
0.610±n/a nM
Citation
 Miyazaki, I; Shimamura, T; Kato, M; Fujita, H Fused pyrimidine compound or salt thereof US Patent  US10233189 Publication Date 3/19/2019 
Target
Name:
Proto-oncogene tyrosine-protein kinase receptor Ret
Synonyms:
CDHF12 | CDHR16 | Cadherin family member 12 | PTC | Proto-oncogene c-Ret | RET | RET51 | RET_HUMAN | Tyrosine-protein kinase Ret (RET)
Type:
Protein
Mol. Mass.:
124318.29
Organism:
Homo sapiens (Human)
Description:
P07949
Residue:
1114
Sequence:
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS
  
Inhibitor
Name:
BDBM370407
Synonyms:
US10233189, Example 29 | US10787457, Example 29 | US11014930, Example 29 | US11236096, Example 29
Type:
Small organic molecule
Emp. Form.:
C20H24N8O
Mol. Mass.:
392.4576
SMILES:
Cc1cc(NC(=O)c2nn(C3C4CC5CC(C4)CC3C5)c3ncnc(N)c23)n[nH]1 |THB:17:15:12:10.19.18,14:15:10:12.13.19,(3.66,6.32,;3.66,4.78,;2.41,3.88,;2.89,2.41,;1.8,1.32,;.31,1.72,;-.08,3.21,;-.77,.63,;.13,-.61,;-.77,-1.86,;-.38,-3.35,;-1.46,-4.44,;-1.07,-5.92,;.42,-6.32,;.52,-5.15,;-.02,-4.84,;-.56,-5.15,;-.02,-4.24,;1.11,-3.75,;1.51,-5.23,;-2.24,-1.38,;-3.57,-2.15,;-4.91,-1.38,;-4.91,.16,;-3.57,.93,;-3.57,2.47,;-2.24,.16,;4.43,2.41,;4.91,3.88,)|
Structure:
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