Reaction Details Report a problem with these data
Target
Focal adhesion kinase 1 [410-689]
Ligand
BDBM418883
Substrate
n/a
Meas. Tech.
In Vitro Activity Assay
IC50
<0.595±n/a nM
Citation
 Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent  US10450297 Publication Date 10/22/2019 
Target
Name:
Focal adhesion kinase 1 [410-689]
Synonyms:
FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32163.33
Organism:
Homo sapiens (Human)
Description:
aa 410-689
Residue:
280
Sequence:
PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
  
Inhibitor
Name:
BDBM418883
Synonyms:
N-{3-[({2-[(4-{[(2- hydroxyethyl)amino]methyl}phenyl)amino]- 5-(trifluoromethyl)pyrimidin-4- yl}amino)methyl]pyridin-2-yl}-N- methylmethane-sulfonamide (383) | US10450297, Example 383
Type:
Small organic molecule
Emp. Form.:
C22H26F3N7O3S
Mol. Mass.:
525.547
SMILES:
CN(c1ncccc1CNc1nc(Nc2ccc(CNCCO)cc2)ncc1C(F)(F)F)S(C)(=O)=O
Structure:
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