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Target
Orexin receptor type 2
Ligand
BDBM370821
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
206±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Heteroaryl orexin receptor antagonists US Patent  US10239838 Publication Date 3/26/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM370821
Synonyms:
2-ethoxy-N-ethyl-N-{2-[6-(1- hydroxy-1-methylethyl)pyridin-2- yl]ethyl}pyridine-3-carboxamide | US10239838, Example 6
Type:
Small organic molecule
Emp. Form.:
C20H27N3O3
Mol. Mass.:
357.4467
SMILES:
CCOc1ncccc1C(=O)N(CC)CCc1cccc(n1)C(C)(C)O
Structure:
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