Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM21983
Substrate
BDBM21974
Meas. Tech.
Enzyme Inhibition Assay
pH
6.5±n/a
Temperature
310.15±n/a K
Comments
Not active @ 500000 nM.
Citation
 Carr, G; Chung, MK; Mauk, AG; Andersen, RJ Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine a. J Med Chem 51:2634-7 (2008) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM21983
Synonyms:
3-(2-aminoethyl)-5,10-diphenyl-1H,4H,11H-anthraceno[2,3-b]pyrrole-4,11-dione | 3-(2-aminoethyl)-5,10-diphenyl-1H-naphtho[2,3-f]indole-4,11-dione | Naphtho[2,3-f]indole-4,11-dione, 24
Type:
Small organic molecule
Emp. Form.:
C30H22N2O2
Mol. Mass.:
442.5079
SMILES:
NCCc1c[nH]c2c1C(=O)c1c(C2=O)c(-c2ccccc2)c2ccccc2c1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM21974
Synonyms:
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHEMBL54976 | L-tryptophan | US11021454, Compound L-trp | US9138393, L-Tryptophan | US9144538, L-Tryptophan
Type:
Amino Acid
Emp. Form.:
C11H12N2O2
Mol. Mass.:
204.2252
SMILES:
N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Structure:
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