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TargetNuclear receptor ROR-gamma
LigandBDBM261446
Substrate/Competitorn/a
Meas. Tech.ROR gamma SPA Binding Assay
Temperature298.15±n/a K
IC50 305±n/a nM
Commentsextracted
Citation Duan, JDhar, TGJiang, BKarmakar, AGupta, AKLu, ZWeigelt, CA Cyclohexyl sulfone RORγ modulators US Patent US9708253 Publication Date 7/18/2017
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Protein
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:Q6I9R9
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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  Blast E-value cutoff:
BDBM261446
NameBDBM261446
Synonyms:US9708253, 105
TypeSmall organic molecule
Emp. Form.C28H24F8N2O3S
Mol. Mass.620.554
SMILESCN([C@H]1CC[C@@](CC1)(c1ccc(cc1)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)c1cccnc1 |r,wU:5.8,wD:2.1,(-4.27,-1.3,;-3.59,-2.69,;-2.06,-2.79,;-1.38,-4.18,;.16,-4.29,;1.02,-3.01,;.34,-1.62,;-1.19,-1.52,;1.02,-1.47,;2.35,-.7,;2.35,.84,;1.02,1.61,;-.32,.84,;-.32,-.7,;1.02,3.15,;-.52,3.15,;1.02,4.69,;1.02,6.23,;2.56,4.69,;-.52,4.69,;2.56,3.15,;4.1,3.15,;2.56,1.61,;3.46,4.4,;2.12,-4.08,;1.06,-5.19,;3.23,-5.15,;3.19,-2.97,;2.77,-1.49,;3.84,-.38,;5.33,-.76,;6.4,.35,;5.76,-2.24,;4.69,-3.34,;-4.45,-3.96,;-3.78,-5.35,;-5.99,-3.86,;-6.85,-5.13,;-8.39,-5.03,;-9.06,-3.64,;-8.2,-2.36,;-6.66,-2.47,)|
Structure
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