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TargetNuclear receptor ROR-gamma
LigandBDBM261451
Substrate/Competitorn/a
Meas. Tech.ROR gamma SPA Binding Assay
Temperature298.15±n/a K
IC50 100.0±n/a nM
Commentsextracted
Citation Duan, JDhar, TGJiang, BKarmakar, AGupta, AKLu, ZWeigelt, CA Cyclohexyl sulfone RORγ modulators US Patent US9708253 Publication Date 7/18/2017
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma
Name:Nuclear receptor ROR-gamma
Synonyms:NR1F3 | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Protein
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:Q6I9R9
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM261451
NameBDBM261451
Synonyms:US9708253, 110
TypeSmall organic molecule
Emp. Form.C29H27F7N2O4S
Mol. Mass.632.59
SMILESCC1(CCC(CC1)(c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)NC(=O)Cc1ccncc1 |(2.79,-.32,;1.49,-1.14,;.81,-2.52,;-.73,-2.63,;-1.59,-1.35,;-.91,.03,;.62,.14,;-1.59,.19,;-.25,.96,;-.25,2.5,;-1.59,3.27,;-2.92,2.5,;-2.92,.96,;-1.59,4.81,;-3.13,4.81,;-1.59,6.35,;-1.59,7.89,;-.05,6.35,;-3.13,6.35,;-.05,4.81,;1.49,4.81,;-.05,3.27,;.86,6.06,;-2.69,-2.42,;-1.62,-3.53,;-3.8,-3.49,;-3.76,-1.31,;-5.26,-1.68,;-6.33,-.58,;-5.9,.9,;-6.97,2.01,;-4.41,1.28,;-3.34,.17,;2.89,-1.76,;3.05,-3.29,;1.81,-4.2,;4.46,-3.92,;4.62,-5.45,;6.03,-6.08,;6.19,-7.61,;4.94,-8.51,;3.54,-7.89,;3.38,-6.36,)|
Structure
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