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Target
D(1A) dopamine receptor
Ligand
BDBM372054
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay for DDR1
IC50
87.7±n/a nM
Citation
Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M; Rudolph, M; Satz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent US10239876 Publication Date 3/26/2019
More Info.:
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
Inhibitor
Name:
BDBM372054
Synonyms:
(RS)-3-[2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one | US10239876, Example 77 | US10435407, Example 77
Type:
Small organic molecule
Emp. Form.:
C26H26F3N7O3
Mol. Mass.:
541.5249
SMILES:
FC(F)(F)CN1CCC(N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1=O