Target
D(1A) dopamine receptor
Ligand
BDBM372144
Substrate
n/a
Meas. Tech.
In Vitro Binding Assay for DDR1
IC50
106±n/a nM
Citation
 Buettelmann, BKocer, BKuhn, BPrunotto, MRichter, HRitter, MRudolph, MSatz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent  US10239876 Publication Date 3/26/2019 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM372144
Synonyms:
(S)-Methyl 4,4-difluoro-1-(2-(4-oxo-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)pyrrolidine-2-carboxylate | US10239876, Example 167 | US10435407, Example 167
Type:
Small organic molecule
Emp. Form.:
C28H29F2N7O5
Mol. Mass.:
581.5706
SMILES:
COC(=O)[C@@H]1CC(F)(F)CN1C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O |r|
Structure:
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