Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM372269
Substrate
n/a
Meas. Tech.
Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity
EC50
405±n/a nM
Citation
 Lindsley, CWConn, PJEngers, DWBollinger, STarr, JCSpearing, PEngers, JLLong, MBridges, TM Positive allosteric modulators of the muscarinic acetylcholine receptor M4 US Patent  US10239887 Publication Date 3/26/2019 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM372269
Synonyms:
8-(azetidin-1-yl)-3,4- dimethylpyrimido [4',5':4,5]thieno[2,3-c] pyridazine | US10239887, Cpd. No. 9
Type:
Small organic molecule
Emp. Form.:
C13H13N5S
Mol. Mass.:
271.341
SMILES:
Cc1nnc2sc3c(ncnc3c2c1C)N1CCC1
Structure:
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