Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM372276
Substrate
n/a
Meas. Tech.
Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity
EC50
>10000±n/a nM
Citation
 Lindsley, CW; Conn, PJ; Engers, DW; Bollinger, S; Tarr, JC; Spearing, P; Engers, JL; Long, M; Bridges, TM Positive allosteric modulators of the muscarinic acetylcholine receptor M4 US Patent  US10239887 Publication Date 3/26/2019 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM372276
Synonyms:
4-(3,3-difluoropyrrolidin- 1-yl)-8-methylpyrido [3',2':4,5]thieno[3,2-d] pyrimidine | US10239887, Cpd. No. 16
Type:
Small organic molecule
Emp. Form.:
C14H12F2N4S
Mol. Mass.:
306.334
SMILES:
Cc1cnc2sc3c(ncnc3c2c1)N1CCC(F)(F)C1
Structure:
Search PDB for entries with ligand similarity: