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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM372330
Substrate
n/a
Meas. Tech.
Cell-Based Functional Assay of Muscarinic Acetylcholine Receptor Activity
EC50
1700±n/a nM
Citation
 Lindsley, CW; Conn, PJ; Engers, DW; Bollinger, S; Tarr, JC; Spearing, P; Engers, JL; Long, M; Bridges, TM Positive allosteric modulators of the muscarinic acetylcholine receptor M4 US Patent  US10239887 Publication Date 3/26/2019 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM372330
Synonyms:
2-[3-[[(3,4- dimethylpyrimido [4',5':4,5]furo[2,3- c]pyridazin-8- yl)amino]methyl] phenyl]propan-2-ol | US10239887, Cpd. No. 67
Type:
Small organic molecule
Emp. Form.:
C20H21N5O2
Mol. Mass.:
363.413
SMILES:
Cc1nnc2oc3c(NCc4cccc(c4)C(C)(C)O)ncnc3c2c1C
Structure:
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