Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM22272
Substrate
BDBM22231
Meas. Tech.
Enzyme Inhibition Assay
IC50
420±10 nM
Citation
 Weinstein, DSLiu, WGu, ZLangevine, CNgu, KFadnis, LCombs, DWSitkoff, DAhmad, SZhuang, SChen, XWang, FLLoughney, DAAtwal, KSZahler, RMacor, JEMadsen, CSMurugesan, N Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase. Bioorg Med Chem Lett 15:1435-40 (2005) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase
Type:
Enzyme
Mol. Mass.:
75309.71
Organism:
Oryctolagus cuniculus (rabbit)
Description:
15-LO enzyme was purified from phenylhydrazine treated rabbits.
Residue:
663
Sequence:
MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSLLFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGDPQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLAWGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPMLLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAPLVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNSHLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMSTGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQHSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRDQPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENSVAI
  
Inhibitor
Name:
BDBM22272
Synonyms:
N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzene-1-sulfonamide | tryptamine sulfonamide, 10
Type:
Small organic molecule
Emp. Form.:
C21H26N2O2S
Mol. Mass.:
370.508
SMILES:
CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22231
Synonyms:
(9Z,12Z)-octadeca-9,12-dienoic acid | CHEMBL267476 | Linoleic Acid | Linoleic acid (LA)
Type:
Unsaturated fatty acid
Emp. Form.:
C18H32O2
Mol. Mass.:
280.4455
SMILES:
CCCCC\C=C/C\C=C/CCCCCCCC(O)=O
Structure:
Search PDB for entries with ligand similarity: