Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM22393
Substrate
Biotinylated TIF2 Peptide
Meas. Tech.
FRET Assay for LRH-1
pH
7.5±n/a
Temperature
295.15±n/a K
EC50
>10000±n/a nM
Citation
 Whitby, RJ; Dixon, S; Maloney, PR; Delerive, P; Goodwin, BJ; Parks, DJ; Willson, TM Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J Med Chem 49:6652-5 (2006) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
  
Inhibitor
Name:
BDBM22393
Synonyms:
(3aS,6aR)-N-(4-tert-butylphenyl)-5-hexyl-4-phenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-amine | bicyclo[3.3.0]-oct-2-ene, 5u
Type:
Small organic molecule
Emp. Form.:
C30H41N
Mol. Mass.:
415.6532
SMILES:
[H][C@]12CCC[C@@]1(Nc1ccc(cc1)C(C)(C)C)C(=C(CCCCCC)C2)c1ccccc1 |r,t:19|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated TIF2 Peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3740.71
Organism:
n/a
Description:
A peptide derived from TIF2 amino acids 732-756.
Residue:
32
Sequence:
ITINQEPVSPKKKENALLRYLLDKDDTKDCNH