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Target
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Ligand
BDBM372968
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Energy Transfer Assay
IC50
8.80±n/a nM
Citation
 Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent  US9895376 Publication Date 2/20/2018 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Synonyms:
C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
72984.33
Organism:
Homo sapiens (Human)
Description:
P04049 Y340D Y341D
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM372968
Synonyms:
US10576087, Compound 2.2b | US9895376, Compound 2.2b
Type:
Small organic molecule
Emp. Form.:
C25H17F3N4O3
Mol. Mass.:
478.4227
SMILES:
FC(F)(F)c1ccc2nc([nH]c2c1)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r|
Structure:
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