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Target
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Ligand
BDBM210005
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Energy Transfer Assay
IC50
3.30±n/a nM
Citation
 Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent  US9895376 Publication Date 2/20/2018 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Synonyms:
C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
72984.33
Organism:
Homo sapiens (Human)
Description:
P04049 Y340D Y341D
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM210005
Synonyms:
US10576087, Compound 2.11 | US9273046, 2.11 | US9895376, Compound 2.11
Type:
Small organic molecule
Emp. Form.:
C24H16F2N4O3
Mol. Mass.:
446.4056
SMILES:
Fc1cc2nc([nH]c2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Structure:
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