Reaction Details Report a problem with these data
Target
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Ligand
BDBM210030
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Energy Transfer Assay
IC50
56.0±n/a nM
Citation
 Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent  US9895376 Publication Date 2/20/2018 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]
Synonyms:
C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
72984.33
Organism:
Homo sapiens (Human)
Description:
P04049 Y340D Y341D
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM210030
Synonyms:
US10576087, Compound 3.4 | US9273046, 3.4 | US9895376, Compound 3.4
Type:
Small organic molecule
Emp. Form.:
C26H15F6N5O2
Mol. Mass.:
543.42
SMILES:
FC(F)(F)c1c[nH]c(n1)-c1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1
Structure:
Search PDB for entries with ligand similarity: