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Target
Vascular endothelial growth factor A
Ligand
BDBM373039
Substrate
n/a
Meas. Tech.
ELISA Assay
EC50
1440±n/a nM
Citation
 Dixon, DD; Grina, J; Josey, JA; Rizzi, JP; Schlachter, ST; Wallace, EM; Wang, B; Wehn, P; Xu, R; Yang, H Aryl ethers and uses thereof US Patent  US9896418 Publication Date 2/20/2018 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
232
Sequence:
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM373039
Synonyms:
US10597366, Compound 274 | US9896418, Compound 274
Type:
Small organic molecule
Emp. Form.:
C17H12F4N2O3S
Mol. Mass.:
400.347
SMILES:
O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=N)(=O)CF |r|
Structure:
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