Reaction Details Report a problem with these data
Target
Steroid hormone receptor ERR1
Ligand
BDBM22420
Substrate
PGC-1 alpha derived peptide
Meas. Tech.
Fluorescence Energy Transfer (FRET) Measurement
pH
7.5±n/a
Temperature
293.15±n/a K
IC50
190±n/a nM
Citation
 Kallen, J; Lattmann, R; Beerli, R; Blechschmidt, A; Blommers, MJ; Geiser, M; Ottl, J; Schlaeppi, JM; Strauss, A; Fournier, B Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem 282:23231-9 (2007) [PubMed]  Article 
Target
Name:
Steroid hormone receptor ERR1
Synonyms:
ERR-alpha | ERR1 | ERR1_HUMAN | ESRL1 | ESRRA | Estrogen receptor-like 1 | Estrogen-Related Receptor, alpha | Estrogen-related receptor alpha | NR3B1 | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1 | Steroid hormone receptor ERR1 alpha | Steroid hormone receptor ERR1/Estrogen-related receptor alpha (ERRa) | von Hippel-Lindau disease tumor suppressor/Steroid hormone receptor ERR1
Type:
PROTEIN
Mol. Mass.:
45508.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1499891
Residue:
423
Sequence:
MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
  
Inhibitor
Name:
BDBM22420
Synonyms:
(cyclohexylmethyl)({[1-(4-methylphenyl)-1H-indol-3-yl]methyl})amine | Indole compound 1a | Inverse agonist
Type:
Small organic molecule
Emp. Form.:
C23H28N2
Mol. Mass.:
332.4818
SMILES:
Cc1ccc(cc1)-n1cc(CNCC2CCCCC2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
PGC-1 alpha derived peptide
Synonyms:
Cy5-labeled PGC-1 alpha derived peptide | peroxisome proliferators-activated receptor coactivator-1 alpha (PGC-1alpha) derived peptide
Type:
Peptide
Mol. Mass.:
1424.68
Organism:
n/a
Description:
n/a
Residue:
12
Sequence:
RPCSELLKYLTT