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Target
Tyrosine-protein kinase ABL1 [64-515]
Ligand
BDBM230749
Substrate
n/a
Meas. Tech.
Radiometric Filter-Binding Assay
IC50
3.00±n/a nM
Citation
 Furet, P; Grotzfeld, RM; Jahnke, W; Jones, D; Manley, PW; Marzinzik, A; Pelle, XF; Salem, B; Schoepfer, J Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent  US9896444 Publication Date 2/20/2018 
Target
Name:
Tyrosine-protein kinase ABL1 [64-515]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51539.77
Organism:
Homo sapiens (Human)
Description:
aa 64-515
Residue:
452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
  
Inhibitor
Name:
BDBM230749
Synonyms:
US9340537, 3 | US9896444, Example 3
Type:
Small organic molecule
Emp. Form.:
C21H18F3N3O4S
Mol. Mass.:
465.446
SMILES:
O[C@H]1CN(C[C@@H]1O)c1ccc(cc1-c1cncs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r|
Structure:
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