Target
Tyrosine-protein kinase ABL1 [64-515]
Ligand
BDBM230761
Substrate
n/a
Meas. Tech.
Caliper Assay
IC50
0.800±n/a nM
Citation
 Furet, PGrotzfeld, RMJahnke, WJones, DManley, PWMarzinzik, APelle, XFSalem, BSchoepfer, J Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent  US9896444 Publication Date 2/20/2018 
Target
Name:
Tyrosine-protein kinase ABL1 [64-515]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51539.77
Organism:
Homo sapiens (Human)
Description:
aa 64-515
Residue:
452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
  
Inhibitor
Name:
BDBM230761
Synonyms:
US9340537, 15 | US9896444, Example 15
Type:
Small organic molecule
Emp. Form.:
C20H18F3N5O2
Mol. Mass.:
417.3844
SMILES:
FC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CCCC3)c(c2)-c2ccn[nH]2)cc1
Structure:
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