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TargetOrexin receptor type 1
LigandBDBM373136
Substrate/Competitorn/a
Meas. Tech.Cell-based Functional Assay
IC50 1.000±n/a nM
Citation Kamenecka, TMHe, YNguyen, WJiang, RSong, XHerr, RJJiang, Q Substituted prolines/piperidines as orexin receptor antagonists US Patent US9896452 Publication Date 2/20/2018
More Info.:Get all data from this article,  Assay Method
 
Orexin receptor type 1
Name:Orexin receptor type 1
Synonyms:Hypocretin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:Protein
Mol. Mass.:47554.50
Organism:Homo sapiens (Human)
Description:O43613
Residue:425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM373136
NameBDBM373136
Synonyms:US9896452, Example 1 | rac-N-((5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)quinoline-8-carboxamide
TypeSmall organic molecule
Emp. Form.C27H25FN4O2S
Mol. Mass.488.576
SMILESCc1nc(C(=O)N2CC(F)CCC2CNC(=O)c2cccc3cccnc23)c(s1)-c1ccccc1
Structure
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