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Target
Egl nine homolog 1 [182-426]
Ligand
BDBM373544
Substrate
n/a
Meas. Tech.
PHD enzymatic assay
IC50
39.8±n/a nM
Citation
 Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors US Patent  US10246442 Publication Date 4/2/2019 
Target
Name:
Egl nine homolog 1 [182-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | HIF-1alpha-PHD2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27392.37
Organism:
Homo sapiens (Human)
Description:
Q9GZT9[182-426]
Residue:
245
Sequence:
NGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM373544
Synonyms:
1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-phenylamino-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid; | US10246442, Example 6 | US10975062, Example 6
Type:
Small organic molecule
Emp. Form.:
C26H20FN5O3
Mol. Mass.:
469.4671
SMILES:
Cc1cccc(C)c1Oc1cc2c(Nc3ccccc3)nc(nc2cc1F)-n1cc(cn1)C(O)=O
Structure:
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