Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [182-426]
Ligand
BDBM373592
Substrate
n/a
Meas. Tech.
PHD enzymatic assay
IC50
126±n/a nM
Citation
Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors US Patent US10246442 Publication Date 4/2/2019
More Info.:
Target
Name:
Egl nine homolog 1 [182-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | HIF-1alpha-PHD2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27392.37
Organism:
Homo sapiens (Human)
Description:
Q9GZT9[182-426]
Residue:
245
Sequence:
NGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
Inhibitor
Name:
BDBM373592
Synonyms:
1-(4-((Cyclohexylmethyl)amino)-6-phenylquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid; | US10246442, Example 49 | US10975062, Example 49
Type:
Small organic molecule
Emp. Form.:
C25H25N5O2
Mol. Mass.:
427.4983
SMILES:
OC(=O)c1cnn(c1)-c1nc(NCC2CCCCC2)c2cc(ccc2n1)-c1ccccc1