Target
Egl nine homolog 1 [182-426]
Ligand
BDBM373643
Substrate
n/a
Meas. Tech.
PHD enzymatic assay
IC50
100±n/a nM
Citation
 Rabinowitz, MHRosen, MDTarantino, KTVenkatesan, H 4-Aminoquinazolin compounds as prolyl hydroxylase inhibitors US Patent  US10246442 Publication Date 4/2/2019 
Target
Name:
Egl nine homolog 1 [182-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | HIF-1alpha-PHD2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27392.37
Organism:
Homo sapiens (Human)
Description:
Q9GZT9[182-426]
Residue:
245
Sequence:
NGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM373643
Synonyms:
1-(4-(Diethylamino)-6-(piperidin-1-yl)quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid; | US10246442, Example 88 | US10975062, Example 88
Type:
Small organic molecule
Emp. Form.:
C21H26N6O2
Mol. Mass.:
394.4701
SMILES:
CCN(CC)c1nc(nc2ccc(cc12)N1CCCCC1)-n1cc(cn1)C(O)=O
Structure:
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