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Target
C-C chemokine receptor type 4
Ligand
BDBM374670
Substrate
n/a
Meas. Tech.
Ca Flux assay
IC50
300±n/a nM
Citation
 Beck, HP; Biannic, B; Bui, MH; Hu, DX; Jackson, JJ; Ketcham, JM; Powers, JP; Reilly, MK; Robles-Resendiz, O; Shunatona, HP; Walker, JR; Wustrow, DJ; Younai, A; Zibinsky, M Chemokine receptor modulators and uses thereof US Patent  US10246462 Publication Date 4/2/2019 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM374670
Synonyms:
3-((S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-yl)pyrrolidin-2-yl)propanoic acid 2,2,2-trifluoroacetate | US10246462, Example 51
Type:
Small organic molecule
Emp. Form.:
C26H32Cl2N6O2
Mol. Mass.:
531.477
SMILES:
C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(CC1)N1CCC[C@H]1CCC(O)=O |r|
Structure:
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