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Target
C-C chemokine receptor type 4
Ligand
BDBM374710
Substrate
n/a
Meas. Tech.
Ca Flux assay
IC50
300±n/a nM
Citation
 Beck, HP; Biannic, B; Bui, MH; Hu, DX; Jackson, JJ; Ketcham, JM; Powers, JP; Reilly, MK; Robles-Resendiz, O; Shunatona, HP; Walker, JR; Wustrow, DJ; Younai, A; Zibinsky, M Chemokine receptor modulators and uses thereof US Patent  US10246462 Publication Date 4/2/2019 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM374710
Synonyms:
US10246462, Example 91
Type:
Small organic molecule
Emp. Form.:
C27H29Cl2N7O
Mol. Mass.:
538.471
SMILES:
CNC(=O)[C@@H]1CCCN1[C@H]1CC=C(C[C@H]1C)c1cnc2c(nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1)C#N |r,c:12|
Structure:
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