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Target
Protein Wnt-3a
Ligand
BDBM375011
Substrate
n/a
Meas. Tech.
Wnt-Luc Reporter Assay
IC50
0.200±n/a nM
Citation
 Cheng, D; Gao, W; Han, D; Pan, S; Zhang, G N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators US Patent  US10251893 Publication Date 4/9/2019 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM375011
Synonyms:
N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-fluoro-4-(2-fluoropyridin-4-yl)phenyl)acetamide | US10251893, Cpd 207
Type:
Small organic molecule
Emp. Form.:
C24H23F2N5O2
Mol. Mass.:
451.4685
SMILES:
CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(c(F)c2)-c2ccnc(F)c2)nc1
Structure:
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