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Target
G protein-coupled receptor kinase 6
Ligand
BDBM375085
Substrate
n/a
Meas. Tech.
TBD
IC50
5920±n/a nM
Citation
 Stewart, AK; Plekhov, A; Greenhouse, R Inhibiting G protein coupled receptor 6 kinase polypeptides US Patent  US10252984 Publication Date 4/9/2019 
Target
Name:
G protein-coupled receptor kinase 6
Synonyms:
GPRK6 | GRK6 | GRK6_HUMAN
Type:
PROTEIN
Mol. Mass.:
66001.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_793895
Residue:
576
Sequence:
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
  
Inhibitor
Name:
BDBM375085
Synonyms:
US10252984, Table 2.46
Type:
Small organic molecule
Emp. Form.:
C11H8F3N3O3S
Mol. Mass.:
319.26
SMILES:
OC(=O)CSc1nnc([nH]1)-c1ccc(OC(F)(F)F)cc1
Structure:
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