Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375122
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
12.0±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375122
Synonyms:
US10253004, Example 36
Type:
Small organic molecule
Emp. Form.:
C29H28FN5O2
Mol. Mass.:
497.5633
SMILES:
Cc1cc(cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cnc(cn1)[C@H]1C[C@@H]1C(O)=O)-c1ccnn1C |r,wU:25.28,14.20,wD:27.32,(-5.95,-3.34,;-5.48,-1.88,;-6.51,-.73,;-6.03,.73,;-4.52,1.05,;-3.49,-.09,;-1.99,.23,;-3.97,-1.56,;-2.94,-2.7,;-3.42,-4.17,;-2.38,-5.31,;-.88,-4.99,;.15,-6.13,;-.4,-3.53,;1,-2.9,;.84,-1.37,;-.66,-1.05,;-1.43,-2.38,;2.32,-3.67,;3.66,-2.9,;3.66,-1.36,;4.99,-.59,;6.32,-1.36,;6.32,-2.9,;4.99,-3.67,;7.66,-.59,;8.99,.18,;8.99,-1.36,;10.33,-.59,;11.66,-1.36,;10.33,.95,;-7.06,1.88,;-8.59,1.72,;-9.22,3.12,;-8.07,4.15,;-6.74,3.38,;-5.33,4.01,)|
Structure:
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