Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM375133
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
19.0±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof US Patent  US10253004 Publication Date 4/9/2019 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM375133
Synonyms:
US10253004, Example 47
Type:
Small organic molecule
Emp. Form.:
C29H27FN4O2S
Mol. Mass.:
514.614
SMILES:
Cc1nc(cs1)-c1cc(C)c(c(C)c1)-c1ccc(F)c2[C@@H](CCc12)Nc1cnc(cn1)[C@H]1C[C@@H]1C(O)=O |r,wU:31.35,20.27,wD:33.39,(-10.73,3.44,;-9.22,3.12,;-8.59,1.72,;-7.06,1.88,;-6.74,3.38,;-8.07,4.15,;-6.03,.73,;-6.51,-.73,;-5.48,-1.88,;-5.95,-3.34,;-3.97,-1.56,;-3.49,-.09,;-1.99,.23,;-4.52,1.05,;-2.94,-2.7,;-3.42,-4.17,;-2.38,-5.31,;-.88,-4.99,;.15,-6.13,;-.4,-3.53,;1,-2.9,;.84,-1.37,;-.66,-1.05,;-1.43,-2.38,;2.32,-3.67,;3.66,-2.9,;3.66,-1.36,;4.99,-.59,;6.32,-1.36,;6.32,-2.9,;4.99,-3.67,;7.66,-.59,;8.99,.18,;8.99,-1.36,;10.33,-.59,;11.66,-1.36,;10.33,.95,)|
Structure:
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