Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM375229
Substrate
n/a
Meas. Tech.
Adenosine A2B Receptor Subtype Competition Radioligand Binding Assay
Ki
4800±n/a nM
Citation
 Castro-Palomino Laria, JC; Camacho Gómez, JA; Mendoza Lizaldez, A Derivatives of 2-aminopyridine as adenosine A2B receptor antagonists and ligands of the melatonin MT3 receptors US Patent  US10253017 Publication Date 4/9/2019 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM375229
Synonyms:
3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyridin-2-amine | US10253017, Example 23
Type:
Small organic molecule
Emp. Form.:
C15H10ClFN4
Mol. Mass.:
300.718
SMILES:
Nc1cc(Cl)c(-c2ccnc(F)c2)c(n1)-c1cccnc1
Structure:
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