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Target
D-amino-acid oxidase
Ligand
BDBM23181
Substrate
BDBM23167
Meas. Tech.
In vitro D-Amino Acid Oxidase Assay
pH
8.5±n/a
Temperature
295.15±n/a K
IC50
23000±300 nM
Citation
 Ferraris, D; Duvall, B; Ko, YS; Thomas, AG; Rojas, C; Majer, P; Hashimoto, K; Tsukamoto, T Synthesis and Biological Evaluation of d-Amino Acid Oxidase Inhibitors. J Med Chem 51:3357-9 (2008) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-Amino Acid Oxidase (DAAO) | D-amino-acid oxidase (DAAO) | DAMOX | DAO | OXDA_PIG
Type:
Flavoprotein
Mol. Mass.:
39338.01
Organism:
Sus scrofa (pig)
Description:
Homodimer.
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVYADRFTPFTTTDVAAGLWQPYTSEPSNPQEANWNQQTFNYLLSHIGSPNAANMGLTPVSGYNLFREAVPDPYWKDMVLGFRKLTPRELDMFPDYRYGWFNTSLILEGRKYLQWLTERLTERGVKFFLRKVESFEEVARGGADVIINCTGVWAGVLQPDPLLQPGRGQIIKVDAPWLKNFIITHDLERGIYNSPYIIPGLQAVTLGGTFQVGNWNEINNIQDHNTIWEGCCRLEPTLKDAKIVGEYTGFRPVRPQVRLEREQLRFGSSNTEVIHNYGHGGYGLTIHWGCALEVAKLFGKVLEERNLLTMPPSHL
  
Inhibitor
Name:
BDBM23181
Synonyms:
7-fluoro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-ol Derivative, 3m
Type:
Small organic molecule
Emp. Form.:
C7H4FNO2
Mol. Mass.:
153.1106
SMILES:
Fc1cccc2c1o[nH]c2=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23167
Synonyms:
(2R)-2-amino-3-hydroxypropanoic acid | CHEMBL285123 | D-Serine
Type:
Amino Acid
Emp. Form.:
C3H7NO3
Mol. Mass.:
105.0926
SMILES:
N[C@H](CO)C(O)=O
Structure:
Search PDB for entries with ligand similarity: