Reaction Details Report a problem with these data
Target
Homoisocitrate dehydrogenase, mitochondrial
Ligand
BDBM23219
Substrate
BDBM23214
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±n/a
Temperature
309.15±n/a K
Ki
790000±n/a nM
Km
18000±n/a nM
kcat
17±n/a 1/sec
Citation
 Yamamoto, T; Miyazaki, K; Eguchi, T Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase. Bioorg Med Chem 15:1346-55 (2007) [PubMed]  Article 
Target
Name:
Homoisocitrate dehydrogenase, mitochondrial
Synonyms:
Homoisocitrate Dehydrogenase (HICDH) | Homoisocitrate dehydrogenase, mitochondrial | LYS10 | LYS11 | LYS12 | LYS12_YEAST | ScHICDH
Type:
Enzyme
Mol. Mass.:
40072.49
Organism:
Saccharomyces cerevisiae
Description:
n/a
Residue:
371
Sequence:
MFRSVATRLSACRGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEGEKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIKTPDLGGKASTQQVVDDVLSRL
  
Inhibitor
Name:
BDBM23219
Synonyms:
(1R,2E)-1-hydroxypent-2-ene-1,2,5-tricarboxylic acid | 3-Carboxypropylidenemalate, 28a
Type:
Small organic molecule
Emp. Form.:
C8H10O7
Mol. Mass.:
218.1608
SMILES:
[H][C@](O)(C(O)=O)C(=C/CCC(O)=O)\C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23214
Synonyms:
(-)-homoisocitric acid | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylic acid | (2R,3S)-Homoisocitrate | Homoisocitrate
Type:
Small organic molecule
Emp. Form.:
C7H10O7
Mol. Mass.:
206.1501
SMILES:
[H][C@](O)(C(O)=O)[C@]([H])(CCC(O)=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: