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Target
L-lactate dehydrogenase
Ligand
BDBM23224
Substrate
BDBM19473
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
87300±1900 nM
Citation
 Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase
Synonyms:
L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH
Type:
Oxidoreductase
Mol. Mass.:
34111.90
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
316
Sequence:
MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA
  
Inhibitor
Name:
BDBM23224
Synonyms:
7-{[4-(formamidoformic acid)-3-methoxyphenyl]methoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 1
Type:
Small organic molecule
Emp. Form.:
C20H15NO10
Mol. Mass.:
429.3338
SMILES:
COc1cc(COc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O
Structure:
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Substrate
Name:
BDBM19473
Synonyms:
2-Oxopropanoate | 2-oxopropanoic acid | Pyruvate
Type:
Small organic molecule
Emp. Form.:
C3H4O3
Mol. Mass.:
88.0621
SMILES:
CC(=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: