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Target
Malate dehydrogenase, mitochondrial
Ligand
BDBM23222
Substrate
BDBM23230
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
IC50
>2000000±n/a nM
Citation
 Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, mitochondrial
Synonyms:
MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial
Type:
Oxidoreductase; homodimer
Mol. Mass.:
35493.48
Organism:
Sus scrofa (pig)
Description:
Porcine heart mitochondria.
Residue:
337
Sequence:
MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFVAELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEKNLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
  
Inhibitor
Name:
BDBM23222
Synonyms:
Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Acid | carbamoylformic acid
Type:
Small organic molecule
Emp. Form.:
C2H3NO3
Mol. Mass.:
89.0501
SMILES:
NC(=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23230
Synonyms:
2-Oxosuccinic acid | 2-oxobutanedioic acid | Oxaloacetate | Oxaloacetic acid | keto-Oxaloacetate
Type:
Small organic molecule
Emp. Form.:
C4H4O5
Mol. Mass.:
132.0716
SMILES:
OC(=O)CC(=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: