Reaction Details Report a problem with these data
Target
Malate dehydrogenase, mitochondrial
Ligand
BDBM23225
Substrate
BDBM23230
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
IC50
96700±n/a nM
Citation
Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed] Article
More Info.:
Target
Name:
Malate dehydrogenase, mitochondrial
Synonyms:
MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial
Type:
Oxidoreductase; homodimer
Mol. Mass.:
35493.48
Organism:
Sus scrofa (pig)
Description:
Porcine heart mitochondria.
Residue:
337
Sequence:
MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFVAELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEKNLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
Inhibitor
Name:
BDBM23225
Synonyms:
7-{2-[4-(formamidoformic acid)phenyl]ethoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 2
Type:
Small organic molecule
Emp. Form.:
C20H15NO9
Mol. Mass.:
413.3344
SMILES:
OC(=O)C(=O)Nc1ccc(CCOc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)cc1