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Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM375586
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
<100.0±n/a nM
Citation
 Nacro, K; Duraiswamy, AJ; Chennamaneni, LR Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof US Patent  US9908886 Publication Date 3/6/2018 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM375586
Synonyms:
4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile | US9908886, Example 145
Type:
Small organic molecule
Emp. Form.:
C27H22F3N5O
Mol. Mass.:
489.4917
SMILES:
CN1CCN(CC1)C(=O)c1ccc(cc1C(F)(F)F)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1
Structure:
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