Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM375769
Substrate
n/a
Meas. Tech.
Enzyme Inhibition
IC50
<1000±n/a nM
Citation
 Jacques, V; Rusche, JR; Peet, NP; Singh, J Histone deacetylase inhibitors US Patent  US9908899 Publication Date 3/6/2018 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM375769
Synonyms:
US10301323, Compound F3 | US9908899, Compound F3
Type:
Small organic molecule
Emp. Form.:
C26H24N4O
Mol. Mass.:
408.495
SMILES:
Nc1ccccc1NC(=O)c1ccc(C=C2CN(Cc3ccc4cc[nH]c4c3)C2)cc1 |(9.46,1.7,;9.46,.16,;10.8,-.61,;10.8,-2.15,;9.46,-2.92,;8.13,-2.15,;8.13,-.61,;6.8,.16,;5.46,-.61,;5.46,-2.15,;4.13,.16,;2.79,-.61,;1.46,.16,;1.46,1.7,;.13,2.47,;-1.21,1.7,;-2.69,2.1,;-3.09,.61,;-4.43,-.16,;-5.76,.61,;-5.76,2.15,;-7.09,2.92,;-8.43,2.15,;-9.89,2.63,;-10.8,1.38,;-9.89,.13,;-8.43,.61,;-7.09,-.16,;-1.6,.21,;2.79,2.47,;4.13,1.7,)|
Structure:
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